Pterostilbene may have antioxidant and anti-aging

4 min read
27 December 2023

Sirtuins are a class of proteins that play a role in regulating various cellular functions, including metabolism, DNA repair, and longevity. Activation of sirtuins has been linked to potential health benefits, including improved metabolic function and increased lifespan. Here are some compounds that are considered sirtuin activators:

### 1. **Resveratrol:**
   - **How it Works:** Found in red wine, grapes, and some berries, resveratrol is one of the most well-known sirtuin activators. It is believed to activate SIRT1, one of the sirtuin proteins.
   - **Sources:** Red wine, grapes, berries, and resveratrol supplements.
   - **Benefits:** Resveratrol may have antioxidant and anti-aging properties, and it is associated with potential cardiovascular benefits.

### 2. **Nicotinamide Riboside (NR):**
   - **How it Works:** NR is a precursor to NAD (nicotinamide adenine dinucleotide), which is involved in sirtuin activation. Higher NAD levels may support sirtuin function.
   - **Sources:** NR supplements.
   - **Benefits:** NR is believed to enhance NAD levels, promoting sirtuin activity and potentially supporting cellular energy production.

### 3. **Nicotinamide Mononucleotide (NMN):**
   - **How it Works:** Similar to NR, NMN is a precursor to NAD and may support sirtuin activation indirectly by boosting NAD levels.
   - **Sources:** NMN supplements.
   - **Benefits:** NMN is thought to enhance cellular energy production and support overall health by influencing sirtuin activity.

### 4. **Fisetin:**
   - **How it Works:** Fisetin is a flavonoid found in strawberries, apples, and onions. It has been suggested to activate sirtuins.
   - **Sources:** Strawberries, apples, onions, and fisetin supplements.
   - **Benefits:** Fisetin may have antioxidant and anti-inflammatory properties, potentially supporting cellular health.

### 5. **Quercetin:**
   - **How it Works:** Quercetin is a flavonoid found in various fruits and vegetables. It is believed to activate sirtuins, particularly SIRT1.
   - **Sources:** Onions, apples, berries, and quercetin supplements.
   - **Benefits:** Quercetin may have anti-inflammatory and antioxidant effects and could contribute to overall cellular health.

### 6. **Pterostilbene:**
   - **How it Works:** Pterostilbene is a compound found in blueberries and grapes. It may activate sirtuins and has structural similarities to resveratrol.
   - **Sources:** Blueberries, grapes, and pterostilbene supplements.
   - **Benefits:** Pterostilbene may have antioxidant and anti-aging properties, potentially supporting cellular health.

### 7. **Butyrate:**
   - **How it Works:** Butyrate is a short-chain fatty acid produced by gut best supplements for zombie cells bacteria during the fermentation of dietary fibers. It is believed to influence sirtuin activity.
   - **Sources:** Dietary fibers, particularly in fruits, vegetables, and whole grains.
   - **Benefits:** Butyrate may support gut health, and its effects on sirtuins could contribute to overall well-being.

### 8. **EGCG (Epigallocatechin Gallate):**
   - **How it Works:** Found in green tea, EGCG is suggested to activate sirtuins and has been associated with potential health benefits.
   - **Sources:** Green tea and EGCG supplements.
   - **Benefits:** EGCG may have antioxidant and anti-inflammatory properties, contributing to cellular health.

It's important to note that while these compounds are associated with sirtuin activation, the research on their effectiveness and long-term health benefits is still evolving. Moreover, individual responses can vary, and more studies are needed to fully understand the implications of sirtuin activation for human health. Before incorporating sirtuin activators into your routine, especially through supplements, it's advisable to consult with a healthcare professional. Additionally, a balanced diet, regular exercise, and other healthy lifestyle practices play crucial roles in supporting overall well-being.

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