The Mechanisms of Fildena 100's Science

The Mechanisms of Fildena 100's Science

Fildena 100 is a medication used to treat erectile dysfunction (ED) in men. It is a phosphodiesterase type 5 (PDE5) inhibitor, which means that it works by blocking the action of PDE5. PDE5 is an enzyme that breaks down cyclic guanosine monophosphate (cGMP), a substance that is responsible for relaxing the muscles in the penis and allowing blood to flow into it. By blocking the action of PDE5, Fildena 100 helps to increase the levels of cGMP in the penis, which relaxes the muscles and allows blood to flow into it, resulting in an erection.
Fildena 100 is taken orally, usually 30 minutes to 1 hour before sexual activity. The dose of Fildena 100 that is right for you will depend on several factors, including your age, overall health, and other medications you are taking. It is important to follow your doctor's instructions carefully when taking Fildena 100.

Fildena 100 is generally well-tolerated, but some side effects may occur. These side effects may include headache, flushing, stomach upset, and nasal congestion. If you experience any side effects from Fildena 100, talk to your doctor.

Fildena 100 is a safe and effective medication for treating ED. It is important to follow your doctor's instructions carefully when taking Fildena 100.

Mechanism of Action

Fildena 100 is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). PDE5 is an enzyme that is responsible for the degradation of cGMP in the corpus cavernosum of the penis. cGMP is a potent vasodilator that relaxes the smooth muscle cells in the corpus cavernosum, allowing blood to flow into the penis and produce an erection.

By inhibiting the degradation of cGMP, Fildena 100 increases the levels of cGMP in the corpus cavernosum, which leads to relaxation of the smooth muscle cells and increased blood flow into the penis. This results in an erection.

Pharmacokinetics

Fildena 100 is rapidly absorbed after oral administration, with peak plasma concentrations occurring within 30-60 minutes. The absolute bioavailability of Fildena 100 is approximately 60%.

Fildena 100 is highly bound to plasma proteins (approximately 95%). The volume of distribution of Fildena 100 is approximately 100 L.

Fildena 100 is metabolized by the cytochrome P450 3A4 isoenzyme. The major metabolites of Fildena 100 are N-desmethylated Fildena 100 and N-oxide Fildena 100.

Fildena 100 is excreted primarily in the feces (approximately 80%) and to a lesser extent in the urine (approximately 20%). The elimination half-life of Fildena 100 is approximately 17 hours.

Clinical Efficacy

Fildena 100 has been shown to be effective in treating ED in men. In clinical trials, Fildena 100 has been shown to improve erectile function, increase the frequency of erections, and reduce the time to achieve an erection.

Safety and Tolerability

Fildena 100 is generally well-tolerated. The most common side effects of Fildena 100 are headache, flushing, stomach upset, and nasal congestion. These side effects are usually mild and transient.

Contraindications

Fildena 100 is contraindicated in patients who are taking nitrates, as this combination can lead to a dangerous drop in blood pressure. Fildena 100 is also contraindicated in patients who have a history of heart disease, stroke, or other cardiovascular problems.

Drug Interactions

Fildena 100 can interact with other medications, including nitrates, alpha-blockers, and antihypertensives. It is important to tell your doctor about all of the medications you are taking before starting Fildena 100.